(1977) carefully examined the biochemical properties of sulfatase activity with both DHEAS and P 5 S as substrates. Sulfatase activity was found in the microsomal fraction prepared from chorion but not amnion. Interestingly, activity was lower in week 10 than at term and three- to fourfold higher activity was observed with membranes from anencephalic fetuses. An early study by Jirásek et al . (1969) indicating 3 β -HSD/Δ 5 − 4 -isomerase activity in the chorion was also extended by Gant et al . (1977) .
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