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HSDs participate in the synthesis and metabolism of sex steroid hormones by catalyzing the conversion of a hydroxy group to a keto group or vice versa on a steroid ring in a specific position and orientation (Yang et al., 2005). Studies on the expression profiles of hsd genes at different stages of grouper sex reversal may provide us a better understanding on the roles of hsd genes in sex reversal. In the gonad, two ( hsd3b1 and hsd17b14 ) and eight ( hsd3b7 , hsd17b1 , hsd17b7l , hsd17b10 , hsd17b12a , hsd17b12b , hsdl1 , and hsdl2 ) β -HSD genes were up- and downregulated during sex reversal, respectively. Hsd3b1 catalyzes the second step of steroidogenesis and is required for the synthesis of all steroids including 11-KT (Hsu et al., 2009). In human testis specimens, HSD17B14 protein has shown immunoreactivity in most of the seminiferous epithelium as well as in peritubular areas harboring Leydig cells (Sivik et al., 2012). Transfection of HSD17B14 in human breast cancer cells significantly decreased the levels of estradiol (Jansson et al., 2006), and further studies have suggested a role for HSD17B14 in the local inactivation of steroid (Lukacik et al., 2007). Therefore, we hypothesized that the increased expression levels of hsd3b1 during the sex reversal of grouper may promote the synthesis of 11-KT, while the increased expression level of hsd17b14 may lead to the inactivation of estradiol in this study. Conclusion. Ponto do bet.It is also perfect for those who love a heap of features packed into a stylish wristwatch.
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My cousin also has two .270 Sherman's, just an improved .270 win with a shortened neck pretty much, both with 8 twists, one is 24.5” the other is 19”, haven't loaded for the shorty yet, but the longer one shoots the 170 EOL great, and it kills well too, lots of pronghorn, a couple mulies at around 600 yards, and an elk at 910. Just a very nice, intermediate set up. With RL26 and your 27” barrel, I would think you could hit 2900 or somewhere in that neighborhood, will be a pretty sweet combo! Thankyou, I didn't know if I was going to run into pressure or velocity issues when running the lighter bullets. I wish the .270's had a larger selection of larger bullets for the long range market. I just hope the 170 berger performs the same as their others after I get my rifle back and I probably won't ever shoot smaller bullets in it again anyway. Well-Known Member. I have a Winchester Model 70 left hand in 270 Winchester Short Magnum, which has a 1:8 twist barrel on it. The original barrel was a 1:10. Well-Known Member.

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