Damage to brain: encephalitis, [26]microcephaly, hydrocephaly, [27]aplasia of brain Damage to the eye: optic stalk, optic cup, and lens vesicles, microphthalmia, cataracts, chorioretinitis, optic atrophy Other neurological disorder: damage to cervical and lumbosacral spinal cord, motor/sensory deficits, absent deep tendon reflexes, anisocoria/Horner's syndrome Damage to body: hypoplasia of upper/lower extremities, anal and bladder sphincter dysfunction Skin disorders: (cicatricial) skin lesions, hypopigmentation. Pathophysiology Edit. Exposure to VZV in a healthy child initiates the production of host immunoglobulin G (IgG), immunoglobulin M (IgM), and immunoglobulin A (IgA) antibodies; IgG antibodies persist for life and confer immunity. Cell-mediated immune responses are also important in limiting the scope and the duration of primary varicella infection. After primary infection, VZV is hypothesized to spread from mucosal and epidermal lesions to local sensory nerves. VZV then remains latent in the dorsal ganglion cells of the sensory nerves. Reactivation of VZV results in the clinically distinct syndrome of herpes zoster (i.e., shingles ), postherpetic neuralgia, [30] and sometimes Ramsay Hunt syndrome type II. [31] Varicella zoster can affect the arteries in the neck and head, producing stroke, either during childhood, or after a latency period of many years.
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